Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first‐order, zero‐order or S‐shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side‐chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.
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Pitt et al. (1997) studied this question.
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