Key result
Coadministration of lofexidine and methadone significantly increased maximal QTc interval (+21.9 msec, p=0.018) and decreased heart rate (-9.6 beats/min, p<0.0001) compared to methadone alone.
Why the study?
Does the coadministration of lofexidine and methadone alter electrocardiographic parameters in adults with opioid dependence?
RCT (n=14)
Double-blind
No
Does the coadministration of lofexidine and methadone alter electrocardiographic parameters in adults with opioid dependence?
Coadministration of lofexidine and methadone induces QTc interval prolongation, requiring cautious prescribing and ECG monitoring, particularly in women.
Answers are grounded in this paper and cite their sources.
Coadministration was associated with QTc prolongation; hypothesis-generating for ECG monitoring in methadone-treated patients pending randomized confirmation.
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Schmittner et al. (2009) conducted an RCT in physical dependence on opioids (n=14). Lofexidine vs. Methadone stabilization alone / Placebo was evaluated on Maximal change in QTc interval (MD 21.9 msec, p=0.018). Coadministration of lofexidine and methadone significantly increased maximal QTc interval (+21.9 msec, p=0.018) and decreased heart rate (-9.6 beats/min, p<0.0001) compared to methadone alone.
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