Key result
High cardiovascular risk factors, including abdominal obesity with hypertension and dyslipidemia, were associated with significantly decreased MGP expression in peripheral blood mononuclear cells.
Why the study?
Matrix Gla protein (MGP) inhibits calcification and prevents vascular wall mineralization, but its expression in PBMC and relationship with CACS and conventional CVD risk factors in adult CVD patients required assessment.
Observational (n=87)
MGP expression in PBMC is decreased in patients with high CVD risk factors, particularly dyslipidemia and abdominal obesity, suggesting it may serve as a biomarker reflecting CVD pathology and lipid metabolism dysregulation.
Answers are grounded in this paper and cite their sources.
Lower PBMC MGP expression links to dyslipidemia and obesity-hypertension; hypothesis-generating for biomarker utility in larger studies.
Objectives Matrix Gla protein (MGP) is a calcification inhibitor that plays a role in preventing soft tissue calcification and local mineralization of the vascular wall. The present study aimed to assess the expression of MGP in Peripheral Blood Mononuclear Cells (PBMC) in adult patients with CVD pathologies and its association with the presence and severity of coronary artery calcium score (CACS) and conventional CVD risk factors. Methods MGP expression was measured in 87 individuals using real time qPCR. Subgrouping was performed according etiologic and metabolic CVD risk factors. Results A clear trend for a decreased MGP expression was observed in all subgroups with high CVD risk. This decrease was significant in abdominally obese hypertensive individuals and in those with dyslipidemia. MGP expression was significantly lower in patients representing high Total cholesterol and LDL cholesterol levels. A positive correlation between MGP expression and smoking status in patients with coronary calcium and in the CVD group was established. Atrial hypertension duration correlated negatively with MGP expression in the group without coronary calcium deposits. Conclusions The current study supports the hypothesis that MGP expression in PBMC probably reflects CVD pathology and is related to lipid metabolism dysregulation.
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Kiselova‐Kaneva et al. (2021) conducted an observational in Cardiovascular disease (n=87). High CVD risk factors (abdominal obesity, hypertension, dyslipidemia) vs. Lower CVD risk subgroups was evaluated on MGP expression in Peripheral Blood Mononuclear Cells (PBMC). High cardiovascular risk factors, including abdominal obesity with hypertension and dyslipidemia, were associated with significantly decreased MGP expression in peripheral blood mononuclear cells.
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