Key result
A feasibility study using spontaneous adverse drug reaction reporting data to recruit patients for pharmacogenetic research on drug-induced arrhythmias achieved an overall participation rate of 9%.
Why the study?
Is it feasible to recruit patients from spontaneous adverse drug reaction reporting systems for pharmacogenetic studies of drug-induced arrhythmias?
Population
45 eligible cases of drug-induced arrhythmias reported to the Netherlands Pharmacovigilance Centre, of which…
Comparison
Pharmacogenetic screening of buccal swab DNA… vs Age, gender, and drug-matched controls.
Design
Case-control
Authors
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Low participation cautions against routine ADR-based recruitment; leaves open whether refined methods can support pharmacogenetic arrhythmia research.
Case-Control (n=9)
Is it feasible to recruit patients from spontaneous adverse drug reaction reporting systems for pharmacogenetic studies of drug-induced arrhythmias?
While feasible, using spontaneous ADR reporting systems for pharmacogenetic research on drug-induced arrhythmias suffers from very low participation rates (9%), primarily due to GP time constraints.
Bruin et al. (2005) conducted a case-control in drug-induced arrhythmias (n=9). Proarrhythmic drugs vs. Age, gender, and drug matched controls was evaluated on Overall participation rate. A feasibility study using spontaneous adverse drug reaction reporting data to recruit patients for pharmacogenetic research on drug-induced arrhythmias achieved an overall participation rate of 9%.
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