An efficient metal‐free oxidative esterification of benzyl CH bonds was developed. Using tetrabutylammonium iodide as catalyst and tert‐butyl hydroperoxide as co‐oxidant, benzylic substrates could react smoothly with various carboxylic acids to give the esters with good to excellent yields. The method was also suitable for the O‐protection of N‐Boc amino acids. The reaction mechanism was primarily investigated and a radical process was proposed.
No takes yet. Share an insight, caveat, or question.
Feng et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: