Key result
A high Intermountain Risk Score independently predicted long-term mortality following transcatheter aortic valve implantation (HR 3.430).
Why the study?
With the increasing use of TAVI, identifying patients at high mortality risk is crucial, prompting evaluation of the laboratory-based Intermountain Risk Score against traditional systems.
Does the Intermountain Risk Score predict long-term mortality in patients undergoing TAVI?
Cohort (n=133)
No
Does the Intermountain Risk Score predict long-term mortality in patients undergoing TAVI?
The Intermountain Risk Score, calculated from routine laboratory parameters, independently predicts long-term mortality following TAVI.
Answers are grounded in this paper and cite their sources.
IMRS may stratify long-term TAVI mortality risk; leaves open superiority over traditional scores pending prospective validation.
BACKGROUND: Since its first introduction, the spectrum and frequency of use of transcatheter aortic valve implantation (TAVI) have increased throughout the world. Therefore, it is crucial to determine which patients are at high mortality risk with TAVI. The Intermountain Risk Score (IMRS) is a score calculated from laboratory parameters. This study aimed to determine the long-term mortality of TAVI patients using the IMRS and to compare it with traditional scoring systems. METHODS: The study included a total of 133 patients undergoing TAVI at our hospital from 2010 to 2019. Demographic data, co-morbid diseases, echocardiographic and laboratory parameters were collected retrospectively. The performance of IMRS was assessed as compared to the mortality determined in the overall patient population. RESULTS: During the follow-up, 54.9% of patients (60 patients) (Group 1) survived; the mortality in Group 2 (60 patients) was 45.1%. The survival period had a mean of 1433 (±124) days. The mean IMRS was 1.67 (0.7) in Group 1 and 2.33 (0.72) in Group 2 (P <0.001). In multivariable analyses, only high risk of IMRS (hazard ratio [HR], 3.430; 95% confidence interval [CI], 1.537-7.653; P = 0.003) and EuroSCORE II (HR, 1.141; 95% CI, 1.011-1.288; P = 0.03) independently predicted long-term mortality. CONCLUSIONS: From the evaluation of all laboratory and echocardiography parameters, long-term mortality (>30 days) following the TAVI procedure can be said to be higher in patients with a high IMRS. The data from this study can be considered of value in demonstrating the clinical significance of IMRS calculation before the TAVI procedure.
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Özdemir et al. (2021) conducted a cohort in Severe aortic stenosis (n=133). High Intermountain Risk Score (IMRS) vs. Low or moderate Intermountain Risk Score was evaluated on Long-term mortality (HR 3.430, 95% CI 1.537-7.653, p=0.003). A high Intermountain Risk Score independently predicted long-term mortality following transcatheter aortic valve implantation (HR 3.430).
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