Why the study?
What is the risk of gastrointestinal toxicity associated with minor analgesics like aspirin and paracetamol?
What is the risk of gastrointestinal toxicity associated with minor analgesics like aspirin and paracetamol?
This review highlights the significant gastrointestinal toxicity risks associated with aspirin compared to the relatively benign gastric profile of paracetamol.
Supports preferring paracetamol over aspirin to limit GI toxicity; leaves open confirmation in modern RCTs.
1 The evidence for the risk of gastric erosions from aspirin is fragmentary. 2 Occult gastric bleeding following aspirin is poorly studied and the skewed distribution is unexplained; platelet factors may be relevant. 3 Overt gastric bleeding may follow aspirin; the risk is probably about one episode per two million doses. 4 There is epidemiological, clinical, experimental and histopathological evidence for an association between chronic aspirin use and chronic gastric ulcer. 5 An alternative to the Davenport hypothesis is proposed to explain the gastric action of aspirin and the non-steroidal anti-inflammatory agents. 6 Paracetamol is probably bland in its gastric actions.
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Duggan Jm (1980) studied this question.
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