P2–095: The differences of behavioral and psychological symptoms in the patients of Alzheimer's disease and vascular dementia

This is the authors' abstract. We don't add key points for this paper.

The behavioral and psychological symptoms (BPSD) that are common in dementia will be helpful for the clinical differentiation between Alzheimer's disease (AD) and vascular dementia (VD). Most previous studies have reported the prevalence and severity of BPSD regardless of severity of progression. However, we evaluated the differences of BPSD between AD and VD with prevalence and severity in progressing of dementia. Also we evaluated differences which were related to the valuable aspects clinically. 141 dementia outpatients from clinics of Busan Gyeongnam Dementia Association in Korea were analyzed. There were 95 patients with AD and 46 with VD. All of the patients took the Korean version of the Neuropsychiatric Inventory (K–NPI) and the expanded version of Korean Clinical Dementia Rating Scale (CDR) and the Korean version of Mini–Mental State Examination (K–MMSE). AD patients revealed a higher number of manifested BPSD symptoms and most subscales showed higher composite scores. But apathy was more severely and frequently manifested in VD. AD patients had more frequent night–time behavior and aberrant motor symptoms above 3 points in CDR 0.5 and VD patients had more frequent apathy symptom above 3 points in CDR 1. These results suggest that AD patients revealed more frequently and severely BPSD than VD patients. Apathy was a more dominant symptom with VD patients. It seemed that some kinds of symptoms were valuable for the differential diagnostic clue even though a better designed study was required.