Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 13, 2010genesisOpen Access

The acc(dta5) mutation diminishes SERCA1 function to a greater degree than other acc alleles through either haploinsufficient or dominant-negative molecular mechanisms.

View Full Paper
Ask AI
Bookmark
Share

Population

Zebrafish embryos (accordion (acc)(dta5) mutants)

Comparison

Mutation in atp2a1/SERCA1 vs Other acc alleles (recessive)

Design

Preclinical

Authors

BOBryan D. OlsonPSParaskevi SgourdouGDGerald B. Downes

Discussion

Loading...

Member takes

Overview

Supports acc(dta5) zebrafish as sensitive Brody disease model; leaves open human translation of SERCA1 mechanisms.

Structured PICO

P
Population
Zebrafish embryos (accordion (acc)(dta5) mutants)
I
Intervention
Mutation in atp2a1/SERCA1
C
Comparator
Other acc alleles (recessive)
O
Outcome
SERCA1 function and swimming behavior (muscle relaxation)surrogate

The acc(dta5) zebrafish mutant harbors a dominant mutation in atp2a1/SERCA1, providing a sensitive model for Brody disease, an exercise-induced impairment of muscle relaxation.

Cite This Study

Olson et al. (2010) studied this question.

synapsesocial.com/papers/6a95163c6a42edee3f2c9941https://doi.org/10.1002/dvg.20631
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA12004 · 79 citations
  2. 2The Accordion Zebrafish tq206 Mutant in the Assessment of a Novel Pharmaceutical Approach to Brody Myopathy2024 · 2 citations
  3. 3ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish2025 · 4 citations
  4. 4Dominant rhabdomyolysis linked to a recurrent <i>ATP2A2</i> variant reducing SERCA2 function in muscle2025 · 5 citations
  5. 5Zebrafishrelatively relaxedmutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease2007 · 125 citations