Glucose Ingestion Mediates a Rapid Increase in the Insulin Responsiveness of Rat Adipocytes

Glucose ingestion produces an increase in the binding affinity of the insulin receptor of rat liver and adipocytes within two and three hours, respectively. This rapid change in binding affinity was accompanied by an increase in the insulin responsiveness of the adipocytes. These findings document the ability of insulin target tissues to quickly modulate their responsiveness to insulin shortly after glucose ingestion