The development and applications of ion-selective membrane electrodes continue to provide excitement in expanding areas of analytical chemistry, including analytical pharmaceutical research and analysis, because these sensors offer the advantages of simple design, construction, and manipulation, reasonable selectivity, fast response time, applicability to colored and turbid solutions, and possible interfacing with automated and computerized systems. The combination of membrane sensors with flow injection analysis (FIA) for the determination of various organic ions of biological interest (e.g., drugs) is a new promising area with many applications. This review covers the material that is of interest to those who deal with ion-selective electrodes in organic and pharmaceutical analysis.
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Coşofre et al. (1993) studied this question.
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