A chemoselective osmium(VI) catalyzed oxidation of benzylic, allylic and propargylic alcohols using K3Fe(CN)6 as a secondary oxidant is described. This protocol is operationally simple and exhibits excellent chemoselectivity favouring the oxidation of benzylic alcohols over the aliphatic alcohols. A larger scale reaction was also found to be compatible.
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Fernandes et al. (2014) studied this question.
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