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The phenomenon of biological specificity is described, and a history of discoveries related to the phenomenon is presented. Aspects of biological specificity described include the mechanism of the immune system, chemotherapy, enzyme‐substrate specificity, neurotransmitters, autoassembly of viruses, autoassembly of subcellular organelles, differentiation, and cellular recognition. A model for biological specificity involving both steric and electrostatic complementarity is presented and the role of structured water and hydrophobic forces is also discussed.
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John Avery (1984) studied this question.
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