S-(+) Camphorsulfonic Acid Glycine (CSAG) as Surfactant-Likes Brønsted Acidic Ionic Liquid for One-Pot Synthesis of ß-Amino Carbonyl

A rapid and efficient S-(+) camphor sulfonic acid Glycine (CSAG), catalyzed, one-pot three-component Mannich reaction has been performed to synthesize ß-amino carbonyl compound at room temperature. The reaction gave desired products in good yield and excellent diastereoselectivity. Products in the presence of CSAG (15 mol%) with yields of 52–89% were obtained. This method offers a new modification and easy working process in mild reaction conditions with a low amount and catalyst recyclability up to at least three periods without significant reduction in performance (efficiency 88–77%). This report describes for the first time the preparation of CSAG catalysts for the synthesis of Mannich products.