Key result
Emerging biomarkers, including micro-RNAs, long non-coding RNAs, and exosomes, show potential for the early diagnosis and monitoring of asymptomatic left ventricular dysfunction and heart failure.
Why the study?
Traditional cardiovascular biomarkers are usually limited to overt cardiac disease, and using emerging biomarkers like micro-RNAs, long non-coding RNAs, and exosome cargo in asymptomatic phases remains a distant goal.
Emerging biomarkers like non-coding RNAs and exosomes show promise for early detection of asymptomatic left ventricular dysfunction, though clinical application remains distant.
May warrant further validation trials before any clinical adoption; leaves open utility in asymptomatic screening.
Heart failure (HF) is one of the major causes of morbidity and mortality worldwide and represents an escalating problem for healthcare systems. The identification of asymptomatic patients with underlying cardiac subclinical disease would create an opportunity for early intervention and prevention of symptomatic HF. Traditional biomarkers are very useful as diagnostic and prognostic tools in the cardiovascular field; however, their application is usually limited to overt cardiac disease. On the other hand, a growing number of studies is investigating the diagnostic and prognostic potential of new biomarkers, such as micro-RNAs (miRNA), long non-coding RNAs, and exosome cargo, because of their involvement in the early phases of cardiac dysfunction. Unfortunately, their use in asymptomatic phases remains a distant goal. The aim of this review is to gather the current knowledge of old and novel biomarkers in the early diagnosis of cardiac dysfunction in asymptomatic individuals.
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Janjusevic et al. (2021) conducted a review in Asymptomatic Left Ventricular Dysfunction. Biomarkers (non-coding RNAs and exosomes) was evaluated. Emerging biomarkers, including micro-RNAs, long non-coding RNAs, and exosomes, show potential for the early diagnosis and monitoring of asymptomatic left ventricular dysfunction and heart failure.
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