Why the study?
Does the coadministration of linezolid and SSRIs cause serotonin syndrome in patients requiring antibiotic therapy?
Population
Patients taking serotonergic antidepressants who require linezolid for the treatment of…
Design
Review
Authors
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Supports individualized risk-benefit decisions over strict SSRI washout with linezolid; leaves open need for prospective incidence data.
Does the coadministration of linezolid and SSRIs cause serotonin syndrome in patients requiring antibiotic therapy?
Coadministration of linezolid and SSRIs carries a rare risk of serotonin syndrome, and decisions to discontinue or delay SSRI therapy should be based on individualized risk-benefit analyses rather than strict washout guidelines.
Quinn et al. (2009) studied this question.