Why the study?
Does coadministration of oral linezolid with pseudoephedrine, phenylpropanolamine, or dextromethorphan alter pharmacokinetic and pharmacodynamic responses?
Design
Other
Authors
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Minimal increases support cautious coadministration with BP monitoring in sensitive patients; extends RCT data on linezolid sympathomimetic interactions.
Does coadministration of oral linezolid with pseudoephedrine, phenylpropanolamine, or dextromethorphan alter pharmacokinetic and pharmacodynamic responses?
Potentiation of sympathomimetic activity by linezolid is generally not clinically significant, but patients sensitive to increased blood pressure should be treated cautiously.
Hendershot et al. (2001) studied this question.
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