Enantiomer-selectivity of the crown ethers I through IV was evaluated by a membrane electrode method. Only chiral crown ether II showed some enantiomer-selectivity for both hydrochloride salts of phenylalanine methylester and phenylethylamine. This method was considered to be a convenient one for screening the enantiomer-selectivity of chiral crown ethers.
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Yasaka et al. (1980) studied this question.
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