We have shown by simultaneous complement receptor lymphocyte rosette and radioautographic techniques that guinea pig, mouse, and rabbit bone marrow-derived (B) cells proliferate in vitro in response to phytohemagglutinin, concanavalin A, pokeweed mitogen, and S. typhosa endotoxin lipopolysaccharide. PHA, Con A, and PWM are predominantly thymus-derived (T) cell mitogens in the guinea pig, mouse and rabbit. LPS is predominantly a B cell stimulant in the guinea pig but predominantly a T cell stimulant in the mouse.
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Elfenbein et al. (1973) studied this question.
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