Direct Amidation of Aldehydes with Primary Amines under Mild Conditions Catalyzed by Diolefin‐Amine–RhI Complexes

Rhodium teaches toleration: The diolefin-amine–RhI complex [Rh(OTf)(trop2NH)(PPh3)] (see scheme) is an effective pre-catalyst for the amidation of a wide range of aldehydes with primary amines. The corresponding amides are obtained in good-to-excellent yields under very mild reactions conditions and a variety of functional groups are tolerated.