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May 7, 2019Antimicrobial Agents and Chemotherapy

In Vivo Pharmacodynamic Profile of Ceftibuten-Clavulanate Combination against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in the Murine Thigh Infection Model

Kamilia Abdelraouf Sean M. Stainton David P. Nicolau

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Abstract

Ceftibuten-clavulanate (CTB-CLA) is a novel β-lactam–β-lactamase combination with potential utility for the management of urinary tract infections caused by extended-spectrum-β-lactamase (ESBL)-producing organisms. We examined the pharmacodynamics of the combination against 25 Enterobacteriaceae expressing β-lactamases (CTX-M, TEM, and SHV wild types and SHV-ESBL) in the murine thigh infection model.

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Abdelraouf et al. (2019) studied this question.

synapsesocial.com/papers/6a9523d87ee17f80122ca33b https://doi.org/10.1128/aac.00145-19

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