Highly Enantioselective Alkenylation of Cyclic α,β‐Unsaturated Carbonyl Compounds as Catalyzed by a Rhodium–Diene Complex: Application to the Synthesis of ( S )‐Pregabalin and (−)‐α‐Kainic Acid

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Rhod to addition: An efficient asymmetric conjugate-addition reaction of alkenyltrifluoroborates and α,β-unsaturated carbonyl compounds, as catalyzed by a rhodium–diene complex, was developed. The products were obtained in high yield and high levels of enantioselectivity. The methodology was applied to a concise synthesis of (S)-pregabalin and (−)-α-kainic acid (see scheme).