Dolichol levels in human brain gray matter increased from 18 micrograms/g in 6-year-old to 263 micrograms/g in 68-year-old human brain gray matter. High performance liquid chromatographic analysis shows dolichols ranging from 14 to 22 isoprene units with 19 isoprene units containing species predominating (approximately 44%). This may be the first report of an appreciable accumulation of a lipid in brains of elderly.
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Pullarkat et al. (1982) studied this question.
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