Why the study?
Is Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) present in the respiratory tract of immunocompetent and immunocompromised patients?
Is Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) present in the respiratory tract of immunocompetent and immunocompromised patients?
XMRV sequences can be detected in respiratory secretions, with a higher prevalence observed in immunocompromised patients compared to immunocompetent carriers.
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XMRV detection in respiratory samples should not change management; leaves open its role as an emerging pathogen in immunocompromised hosts.
Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2%-3% of samples from 168 immunocompetent carriers and approximately 10% of samples from 161 immunocompromised patients.
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Fischer et al. (2010) studied this question.
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