Solid‐Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage

Oligonuclecotides bearing phosphoramidate internucleotide linkages can be prepared chemically by standard solid‐phase DNA synthesis. Thus, phosphoramidate internucleotide bonds can be placed at will into specific positions within a given DNA fragment. The backbone‐modified DNA fragments prepared in this way are susceptible to a specific chemical cleavage.