September 1, 1998The Journal of Clinical Endocrinology & MetabolismOpen Access

The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency1

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Population

10 independently ascertained combined pituitary hormone deficiency kindreds and 21 sporadic cases of CPHD…

Design

Cross-sectional

Authors

JCJoy D. CoganVanderbilt University Medical Center WWWei WuHuanggang Normal University IAIvo J.P. ArnholdAssociação Paulista para o Desenvolvimento da Medicina

Discussion

Member takes

Implication

Supports targeted PROP1 testing in familial CPHD; leaves open its role and utility in sporadic cases.

Structured PICO

Population

10 independently ascertained combined pituitary hormone deficiency (CPHD) kindreds and 21 sporadic cases of CPHD from 8 different countries

Outcome

Frequency of the 301-302delAG deletion in exon 2 of the PROP1 gene

The PROP1 301-302delAG deletion is a common, likely recurring mutation responsible for a significant proportion of familial combined pituitary hormone deficiency.

Cite This Study

Cogan et al. (1998) studied this question.

synapsesocial.com/papers/6a952aa4aec9be1889e3c768 https://doi.org/10.1210/jcem.83.9.5142

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The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider