Patients with obliterative cardiomyopathies exhibit specific glomerular lesions that likely result from the deposition and organization of immune complexes.
May prompt renal assessment in endomyocardial fibrosis; leaves open immune complex role pending larger studies.
Electron and, or light microscopic examination of paraffin embedded renal tissue obtained from necropsies on eleven patients with obliterative cardiomyopathy showed a variety of abnormalities. Glomerular lesions present in patients with endomyocardial fibrosis included capillary wall thickening, basement membrane duplication, mesangial expansion and interposition, intraluminal fibrin and dense subendothelial deposits. These changes, some of which have been reported earlier in patients with Loffler's endocarditis, probably result from deposition and organisation of immune complexes.
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Date et al. (1983) studied this question.
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