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A new water‐soluble N‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, has been prepared and its application to solid phase peptide synthesis in water has been studied. Leu‐enkephalin amide was successfully synthesized in water by the solid phase method using this protecting group.
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Hojo et al. (2001) studied this question.
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