In 200 fact-filled pages, Wallace Park divulges the results of his more than two decades of devoted study of the pathophysiologic intricacies of the trophoblast. Following an opening, brief, but thorough survey of the historical highlights of trophoblastic neoplasia, he discusses in detail the confusing and controversial aberrations of these novel and bizarre lesions. The foibles and frustrations, facts and fancies surrounding this strangely acceptable allograft are woven into the fabric of this monograph. Controversial opinions concerning the genesis, behavior, and host reaction are debated and, insofar as possible, the author presents and defends the validity of his favorite thesis. The usual problems of trophoblastic disease are discussed, including the place of prior pregnancy, terminology, and the differential in malignant potential between proliferative and nonproliferative moles, a feature never well documented by any investigator. Most challenging is the analysis of potential etiologic factors, including a proposal that a virus fulfills
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J. Donald Woodruff (1972) studied this question.