Hereditary spastic paraplegia

This is the authors' abstract. We don't add key points for this paper.

Hereditary spastic paraplegia is a rare disease, the first mention of it in the literature probably being by Strumpell (1880), after whom the disease is sometimes named. Rhein (1916), gave a summary of all reports up to that date, 90 in all covering 111 families, and Paskind and Stone (1933) also summarized the literature with accounts of another 36 reports from 40 families. Since then about 50 further reports have appeared, covering some 60 families, bringing the total so far to 176 reports of 215 families. Of these the majority have originated in Germany or elsewhere in Europe, but with a substantial number from the Americas.