Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an alpha-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.
No takes yet. Share an insight, caveat, or question.
Stauffer et al. (2000) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: