BACKGROUND/AIMS: Skin atrophy manifests itself as fragile and easily bruised skin, telangiectasia and striae distensae. METHODS: Various methods have been used to predict the atrophogenicity potential of topical corticosteroids in man. Assay standardization, including reference corticosteroid, anatomic site, method of administration, and quantification, has not been accomplished. RESULTS/CONCLUSION: This report reviews the literature and proposes a standard assay method.
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Lee et al. (1998) studied this question.
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