March 11, 2010Journal of Applied Physiology
Modification of angiogenic factors by regular and acute exercise during pregnancy
Why the study?
Does regular and acute exercise alter angiogenic markers associated with preeclampsia risk in healthy pregnant women?
Population
52 normotensive, nonsmoking women, comprising 25 pregnant women and 27 nonpregnant women.
Comparison
Regular exercise and acute exercise. vs Inactive women and pre-exercise baseline.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Active lifestyle in pregnancy was associated with favorable angiogenic markers; leaves open causal effects on preeclampsia risk.
Structured PICO
Does regular and acute exercise alter angiogenic markers associated with preeclampsia risk in healthy pregnant women?
P
Population
52 normotensive, nonsmoking women, comprising 25 pregnant women (16 active, 9 inactive, 34.1+/-1.6 weeks gestation) and 27 nonpregnant women (15 active, 12 inactive, midlate luteal phase).
I
Intervention
Regular exercise (at least 3 hours/week) and acute exercise (20 minutes of moderate-intensity cycle ergometry).
C
Comparator
Inactive women (no regular exercise at an intensity sufficient to cause sweating) and pre-exercise baseline.
O
Outcome
Serum concentrations of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng).surrogate
Regular exercise during pregnancy is associated with a more favorable angiogenic profile, which may contribute to a reduced risk of preeclampsia.
Cite This Study
Weissgerber et al. (2010) studied this question.