Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

To the Editor: Ware et al. (Jan.21 issue) 1 describe a very similar distribution of presumably causative genetic variants in TTN and other genes in women with peripartum cardiomyopathy and in persons with idiopathic dilated cardiomyopathy.The clinical outcome of peripartum cardiomyopathy is highly variable, ranging from full recovery to rapid progression to end-stage heart failure, 2 and the appropriate duration of therapy is controversial.I therefore wonder whether analysis of the data of Ware et al. can shed light on whether TTN-truncating variants are associated with late recovery or persistent left ventricular dysfunction in patients with peripartum cardiomyopathy.