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F marks the spot: We report a new technique for selectively labeling Trp side chains in proteins with 19F by using 3β-indoleacrilic acid as an inhibitor of tryptophan biosynthesis. Our method finds useful application in the study of protein–protein or protein–ligand interactions (see figure) by means of 19F NMR spectroscopy.
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Leone et al. (2003) studied this question.
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