Wound Healing: Types, Mechanisms, and Therapeutic Approaches with Bioactive Compounds and Herbs

The complex interaction of blood cells, tissues, soluble mediators, cytokines, and other growth factors is essential for wound healing, whether it is surgical or accidental. Plants are appreciated for their flavor, aroma, and medicinal properties. Herbs have been used across many cultural traditions, including spiritual practices, medicine, and cooking. Since ancient times, medicinal plants have played an important role in treating a wide variety of illnesses and health issues. This is mainly because medicinal plants generally do not cause adverse side effects. With a diverse range of plant species and easy access to traditional medicinal methods, India is one of the world's richest sources of biodiversity. According to WHO data and other relevant sources, more than 80% of people worldwide use herbal medicines. The purpose of this review article is to highlight the significance of herbal agents in medicine, especially unrefined plant extracts. Because they contain a wide range of beneficial active phytoconstituents, plants hold great potential for wound care, treatment, and tissue regeneration. This article offers detailed information on several important plants and their extracts, emphasising their roles in wound healing, along with the mechanisms of action and published scientific research. Additionally, it provides a comprehensive analysis of various in-vitro, exvivo, and in-vivo models used to evaluate wound healing activities.