Key result
A 62-year-old woman with tamponade and complete AV block was diagnosed with fatal primary cardiac high-grade B-cell non-Hodgkin's lymphoma using immunohistochemical and molecular techniques.
Case Report (n=1)
This case highlights the importance of immunohistochemical and molecular techniques in accurately diagnosing primary cardiac lymphoma.
Primary cardiac lymphoma merits consideration in tamponade with AV block; single case report leaves diagnostic and therapeutic questions open.
We report a fatal primary cardiac non-Hodgkin's lymphoma in a 62 years old immunocompetent woman presenting with tamponade and complete atrioventricular block. CT-scan, echocardiography and autopsy examination showed a tumor largely infiltrating the heart without extracardiac involvement. A surgical biopsy revealed high grade B-cell non-Hodgkin's lymphoma with a misleading myelomonocytic CD68 (KPI) expression. Polymerase Chain Reaction analysis revealed a clonal rearrangement of the immunoglobulin heavy chain gene and confirmed the B-cell origin of the lymphoma. Our report also emphasizes the role of immunohistochemical and molecular techniques in the diagnosis.
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Bégueret et al. (1998) conducted a case report in Primary cardiac non-Hodgkin's lymphoma (n=1). A 62-year-old woman with tamponade and complete AV block was diagnosed with fatal primary cardiac high-grade B-cell non-Hodgkin's lymphoma using immunohistochemical and molecular techniques.
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