Key result
Reduction of arterial pH to severe acidemia (6.8 to 7.0) resulted in no significant impairment of left ventricular function or catecholamine responsiveness in newborn lambs.
Why the study?
Does severe acidemia induced by acid infusion impair left ventricular function in newborn lambs?
Does severe acidemia induced by acid infusion impair left ventricular function in newborn lambs?
Severe acidemia does not significantly impair left ventricular function or catecholamine responsiveness in newborn lambs, suggesting a strong myocardial buffering capacity.
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Severe acidemia may spare neonatal LV function; leaves open translation to human infants and clinical practice.
Talner et al. (1966) studied Acidemia (n=20). Severe acidemia (hydrochloric or lactic acid infusion) vs. Normal arterial pH (7.35 to 7.5) was evaluated on Left ventricular function (stroke volume, mean ejection rate, responsiveness to catecholamine). Reduction of arterial pH to severe acidemia (6.8 to 7.0) resulted in no significant impairment of left ventricular function or catecholamine responsiveness in newborn lambs.
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