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January 1, 2013Open Access

Overall 10-year freedom from AV re-intervention was significantly lower in patients with PG ≥20 mmHg compared to PG <20 mmHg (76.8±8.4% vs. 89.1±3.0%, P=0.02), while 10-year cardiac survival was similar (89.5±4.2% vs. 82.3±4.6%, P=0.53).

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Why the study?

Does a higher post-operative valve gradient (≥20 mmHg) increase the risk of valve re-intervention and death in patients undergoing aortic valve repair?

Population

471 patients who underwent aortic valve repair (AVr) between March 1996 and June 2010.

Comparison

Post-operative peak gradient (PG) ≥20 mmHg (n=113) vs Post-operative peak gradient (PG) <20 mmHg (n=358)

Design

Cohort

Follow-up

Mean 123.1±89.7 months for Group I and 147.1±108.0 months…

Authors

HVHunaid A. VohraRWRobert N. WhistanceLKLaurent de Kerchove

Discussion

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Member takes

Overview

PG ≥20 mmHg after aortic valve repair was associated with higher re-intervention rates; hypothesis-generating for gradient targets and warrants prospective confirmation.

Structured PICO

Does a higher post-operative valve gradient (≥20 mmHg) increase the risk of valve re-intervention and death in patients undergoing aortic valve repair?

P
Population
471 patients who underwent aortic valve repair (AVr) between March 1996 and June 2010.
I
Intervention
Post-operative peak gradient (PG) ≥20 mmHg (n=113)
C
Comparator
Post-operative peak gradient (PG) <20 mmHg (n=358)
O
Outcome
Freedom from valve re-intervention and deathhard clinical

A higher post-operative peak gradient (≥20 mmHg) after aortic valve repair is associated with a significantly higher rate of long-term valve re-intervention, particularly in younger patients.

Cite This Study

Vohra et al. (2013) studied this question.

synapsesocial.com/papers/6a954591aa92d0f3572c9cadhttps://doi.org/10.3978/j.issn.2225-319x.2012.12.02
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aortic valve repair leads to a low incidence of valve-related complications2009 · 314 citations
  2. 2Hemodynamic and clinical impact of prosthesis–patient mismatch in the aortic valve position and its prevention2000 · 676 citations
  3. 3Evaluation of Transmitral Pressure Gradients in the Intraoperative Echocardiographic Diagnosis of Mitral Stenosis after Mitral Valve Repair2011 · 39 citations
  4. 4Structure, stress, and tissue repair in aortic valve leaflets1988 · 56 citations
  5. 5Valve Configuration Determines Long-Term Results After Repair of the Bicuspid Aortic Valve2011 · 372 citations