Key result
Carpentier-Edwards pericardial and supraannular bioprostheses provided similar life expectancy (10.8 vs 10.9 years for a 65-year-old male) and long-term outcomes after aortic valve replacement.
Why the study?
Does the Carpentier-Edwards pericardial bioprosthesis improve life expectancy and reduce structural valvular deterioration compared to the Carpentier-Edwards supraannular bioprosthesis in patients undergoing aortic valve replacement?
Population
6,481 patients >15 years of age undergoing predominantly first-time aortic valve replacement with or without…
Comparison
Carpentier-Edwards pericardial bioprosthesis vs Carpentier-Edwards supraannular bioprosthesis
Design
Meta-analysis
Follow-up
12,250 patient-years and 20,127 patient-years
Authors
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Supports equivalent selection of either bioprosthesis for AVR; confirms comparable durability in meta-analyzed cohorts.
Meta-Analysis (n=6,481)
Yes
Does the Carpentier-Edwards pericardial bioprosthesis improve life expectancy and reduce structural valvular deterioration compared to the Carpentier-Edwards supraannular bioprosthesis in patients undergoing aortic valve replacement?
Absolute Event Rate: 18.3% vs 14%
Microsimulation based on meta-analysis data suggests similar life expectancy but slightly different lifetime risks of reoperation due to structural valvular deterioration between Carpentier-Edwards pericardial and supraannular bioprostheses.
Puvimanasinghe et al. (2006) conducted a meta-analysis in Aortic valve replacement (n=6,481). Carpentier-Edwards pericardial bioprosthesis vs. Carpentier-Edwards supraannular bioprosthesis was evaluated on Lifetime risk of reoperation due to structural valvular deterioration (SVD) for a 65-year-old male. Carpentier-Edwards pericardial and supraannular bioprostheses provided similar life expectancy (10.8 vs 10.9 years for a 65-year-old male) and long-term outcomes after aortic valve replacement.
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