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The purpose of this study was to investigate the effect of Collagen/hyaluronic acid (Col/HA) polyelectrolyte multilayer (PEM) coating on the behaviors and function of pre‐osteoblastic cells. Col/HA PEM coating was fabricated on acid etched Ti disc via layer‐by‐layer technique. The formation and properties of Col/HA PEM coating were investigated using scanning electron microscope (SEM), contact angle and quartz crystal microbalance (QCM). Moreover, mouse preosteoblasts were used to evaluate the effect of Col/HA PEM coating on cell behaviors and function. The results of in vitro evaluations showed that the Col/HA PEM coating could accelerate the proliferation and differentiation of preosteoblasts cells.
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Li et al. (2011) studied this question.
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