Key result
The helix-based RNA folding theory provides a conceptual framework using helices as building blocks to calculate folding kinetics of secondary structures with pseudoknots of long RNA.
Why the study?
Fully understanding RNA biological functions requires investigating the folding kinetics of RNA molecules rather than native structures alone.
This review summarizes the helix-based RNA folding theory and its application in exploring regulation mechanisms of riboswitches and self-cleavage activities of the HDV ribozyme.
May guide RNA therapeutic modeling; leaves open experimental validation before cardiovascular applications.
RNAs carry out diverse biological functions, partly because different conformations of the same RNA sequence can play different roles in cellular activities. To fully understand the biological functions of RNAs requires a conceptual framework to investigate the folding kinetics of RNA molecules, instead of native structures alone. Over the past several decades, many experimental and theoretical methods have been developed to address RNA folding. The helix-based RNA folding theory is the one which uses helices as building blocks, to calculate folding kinetics of secondary structures with pseudoknots of long RNA in two different folding scenarios. Here, we will briefly review the helix-based RNA folding theory and its application in exploring regulation mechanisms of several riboswitches and self-cleavage activities of the hepatitis delta virus (HDV) ribozyme.
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Gong et al. (2020) conducted a review in RNA folding. Helix-based RNA folding theory was evaluated. The helix-based RNA folding theory provides a conceptual framework using helices as building blocks to calculate folding kinetics of secondary structures with pseudoknots of long RNA.
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