Why Should Internists Be Interested in Interleukin-1?

Editorials1 July 1988Why Should Internists Be Interested in Interleukin-1?Ruth Neta, PhD, Joost J. Oppenheim, MDRuth Neta, PhDSearch for more papers by this author, Joost J. Oppenheim, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterleukin-1 is a hormone-like polypeptide produced in response to infection, injury, physiologic stress, or antigenic challenge. Originally named for its ability to act as an intercellular signal between leukocytes, interleukin-1 has pleiotropic effects on tissues and organs (1). Fever, elevation of acute-phase reactive proteins, and neutrophilia are some responses to systemic interleukin-1 that make it a key mediator of inflammation (2). As an inflammatory mediator, interleukin-1 may be both beneficial and harmful. Current studies focus on possible therapeutic uses of interleukin-1 itself, as well as its agonists and antagonists. Although the availability of large quantities of recombinant interleukin-1 has made...References1. OppenheimKovacsMatsushimaDurum JEKS. There is more than one interleukin 1. Immunol Today. 1986;7:45-56. CrossrefMedlineGoogle Scholar2. Dinarello C. Interleukin-1. Rev Infect Dis. 1984;6:51-95. CrossrefMedlineGoogle Scholar3. Lepe-ZunigaGery JI. Production of intracellular and extracellular interleukin-1 (IL-1) by human monocytes. Clin Immunol Immunopathol. 1984;31:222-30. CrossrefMedlineGoogle Scholar4. Dinarello C. Biology of interleukin 1. FASEB J. 1988;2:108-15. CrossrefMedlineGoogle Scholar5. DurumOppenheimNeta SJR. Immunophysiological role of interleukin-1. In: Oppenheim JJ, Shevach E, eds. Immunophysiology: Role of Cells and Cytokines in Immunity and Inflammation. Oxford University Press; 1988. In press. Google Scholar6. Besedovskydel ReySorkinDinarello HAEC. 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CrossrefMedlineGoogle Scholar15. MovatCybulskyColditzChanDinarello HMIMC. Acute inflammation in gram negative infection: endotoxin, interleukin-1, tumor necrosis factor, and neutrophils. Fed Proc. 1987;46:97-104. MedlineGoogle Scholar16. NakamuraNakataKashimotiYoshidaYamada SKSHM. Antitumor effect of recombinant human interleukin-1 alpha against murine syngeneic tumors. Jpn J Cancer Res. 1986;77:767-73. MedlineGoogle Scholar17. Van der MeerBarzaWolffDinarello JMSC. Low dose recombinant interleukin-1 protects granulocytopenic mice from lethal gram-negative infection. Proc Natl Acad Sci USA. 1988. In press. CrossrefMedlineGoogle Scholar18. NetaDouchesOppenheim RSJ. Interleukin 1 is a radioprotector. J Immunol. 1986;136:2483-8. MedlineGoogle Scholar19. Neta R. Cytokines in radioprotection and therapy of radiation injury. Biotherapy. 1988. In press. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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