Respiratory Absorption Data and SO2Dose-Response Curves

The author's studies can be grouped to give SO/sub 2/ dose-response curves from 0.1 to 800 ppM (0.4 to 100 ppM with tracheal cannula) with response as pulmonary flow resistance. The author uses Strandberg's data on rabbits to estimate lung penetration in her experiments with guinea pigs, and so straightens curve on log-log scale and puts it in line with data from tracheal cannula. At low ppM upper respiratory absorption is minimal, so data from nose and tracheal inputs are similar. At higher concentrations, tracheal input gives greater response.