The Expression Levels and Clinical Significance of CARDS TX, MyD88, and IL‐8 of Children With Severe Mycoplasma pneumoniae Pneumonia

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OBJECTIVE: To investigate the expression levels of community-acquired respiratory distress syndrome toxin (CARDS TX), myeloid differentiation factor 88 (MyD88), and interleukin-8 (IL-8) in the bronchoalveolar lavage fluid (BALF) of children with severe Mycoplasma pneumoniae pneumonia (SMPP) and explore their clinical significance in the pathogenesis of SMPP. METHODS: This was a retrospective analysis of clinical data from 29 patients with SMPP and 12 patients with general Mycoplasma pneumoniae pneumonia (GMPP). Moreover, the expression levels of CARDS TX, MyD88, and IL-8 in the BALF of the two groups were detected and compared. RESULTS: The expression levels of CARDS TX, MyD88, and IL-8 were positively correlated with SMPP (p < 0.05). Univariate logistic regression analysis indicated that CARDS TX, MyD88, and IL-8 are potential risk factors for SMPP (p < 0.05). The areas under the curve for the CARDS TX, MyD88, and IL-8 assays were 0.857, 0.730, and 0.799, respectively. The optimal cutoff values were 10.91 ng/mL, 2.21 ng/mL, and 120.52 pg/mL, respectively. CONCLUSIONS: Elevated levels of CARDS TX, MyD88, and IL-8 in BALF all demonstrate diagnostic utility for children with SMPP, with CARDS TX exhibiting the highest diagnostic sensitivity. A CARDS TX concentration >10.91 ng/mL, a MyD88 concentration >2.21 ng/mL, and an IL-8 concentration >120.52 pg/mL are potential risk factors for SMPP.