Gold simplifies matters: Gold manno-glyconanoparticles displaying different densities of linear and branched mannose oligosaccharides acted as inhibitors of DC-SIGN-mediated HIV trans-infection of human activated peripheral blood mononuclear cells. Presentation of simple linear di-, tri-, and tetraoligosaccharides on the nanoclusters resulted in efficiencies similar to those observed for complex branched penta- and heptamannosides.
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Martínez‐Ávila et al. (2009) studied this question.
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