Histidine side chains in helical structures catalyse the acylation of flanking lysine, ornithine and 1,3-diaminobutyric acid residues provided they are in positions i - 3 and i + 4, but not in positions i - 4, i - 1, i + 2, i + 3, relative to a histidine in position i, in a novel site-selective functionalization reaction that enhances the potential of polypeptide and protein design.
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Broo et al. (1997) studied this question.
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