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Animal study demonstrates progressive viral adaptation and immune decline during SIVcpz infection in humanized mice, highlighting molecular pathways driving HIV-1 emergence.
HIV‐1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species transmission. Increasing viral loads, CD4+ T‐cell decline, and non‐synonymous mutations were seen in the entire genome reflecting viral adaptation.
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Curlin et al. (2019) studied this question.
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