SiteComp: a server for ligand binding site analysis in protein structures

Motivation: Computational characterization of ligand-binding sites in proteins provides preliminary information for functional annotation, protein design and ligand optimization. SiteComp implements binding site analysis for comparison of binding sites, evaluation of residue contribution to binding sites and identification of sub-sites with distinct molecular interaction properties. Availability and implementation: The SiteComp server and tutorials are freely available at http://sitecomp.sanchezlab.org Contact: roberto@sanchezlab.org; roberto.sanchez@mssm.edu Supplementary information: Supplementary data are available at Bioinformatics online.