The rates of N-oxide formation from pyridine, nicotinamide and isonicotinamide by rat liver microsomes and by cultured rat hepatocytes have been quantified using a simple h.p.l.c. system. 2. Hepatocytes produce hetero-aromatic N-oxides for at least 5 h, making them a useful system to study the N-oxidation of pyridines.
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Blaauboer et al. (1980) studied this question.
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